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The Wallenberg Neuroscience Center (WNC) was established in 1996 as a joint venture between Lund University and Skåne University Hospital. The WNC building was partly funded by a major grant from the Knut and Alice Wallenberg Foundation as…

https://www.wnc.lu.se/about-us- 2021-03-17

A revolution in the study of monoamine systems in the CNS Long before the modern era of selective and sensitive antibodies that have allowed virtually any protein of choice to be visualized immunohistochemically, the monoamine…

https://www.wnc.lu.se/about-us/falck-hillarp-method- 2023-01-09

Scientists in Lund have pioneered the use of fetal dopamine neurons for transplantation in Parkinson´s Disease. This approach was developed from 1979-1983 in a series of animal experimental studies (publications 1 below), followed by more…

https://www.wnc.lu.se/cell-therapy-parkinsons-disease- 2021-02-23

    We are located in the Biomedical Center (BMC) in Lund in the south of Sweden.  Our visiting address is Sölvegatan 17. How to get to Lund From Copenhagen airport:  Copenhagen airport Kastrup (CPH) is Denmark's international airport, and…

https://www.wnc.lu.se/about-us/visit-us- 2021-03-11

PII: 0006-8993(80)90692-7 Brain Research, 199 (1980) 307-333 0 Elsevier/North-Holland Biomedical Press 307 RElNNERVATION OF THE DENERVATED STRIATUM BY SUBSTANTlA NIGRA TRANSPLANTS : FUNCTIONAL CONSEQUENCES AS REVEALED BY PHARMACOLOGICAL…

https://www.wnc.lu.se/sites/wnc.lu.se/files/bjorklund_et_al_brain_res_1980.pdf

https://www.wnc.lu.se/sites/wnc.lu.se/files/brundin.pdf

Parkinson’s disease (PD) is the most com- mon cause of movement disorder and has a median age-of-onset of ~55 years. It presents with a classical triad of motor symptoms: akinesia, rigidity and tremor. Many patients also suffer from non…

https://www.wnc.lu.se/sites/wnc.lu.se/files/brundin_et_al_nature_rev_neurosci_2008.pdf

PII: 0006-8993(81)90498-4 Brain Research, 215 (1981) 147-161 © Elsevier/North-Holland Biomedical Press 147 B E H A V I O U R A L RECOVERY F O L L O W I N G T R A N S P L A N T A T I O N OF SUBSTANTIA N I G R A IN RATS SUBJECTED TO 6-OHDA…

https://www.wnc.lu.se/sites/wnc.lu.se/files/dunnett_et_al_part_i_brain_res_1981.pdf

PII: 0361-9230(82)90113-7 Brain Research Bulkfin, Vol. 9, pp. xi-xv, 1982. Printed in the U.S.A. Fluorescence of Catechol Amines and Related Compounds Condensed With Formaldehyde”” B. FALCK, N.-A. HILLARP, G. THIEME AND A. TORP Department…

https://www.wnc.lu.se/sites/wnc.lu.se/files/falck_1962.pdf

https://www.wnc.lu.se/sites/wnc.lu.se/files/falck_and_torp_1962.pdf

untitled Copyright 2013 American Medical Association. All rights reserved. Long-term Clinical Outcome of Fetal Cell Transplantation for Parkinson Disease Two Case Reports Zinovia Kefalopoulou, MD, PhD; Marios Politis, MD, PhD; Paola…

https://www.wnc.lu.se/sites/wnc.lu.se/files/kefalopoulou_jama_neurol.pdf

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https://www.wnc.lu.se/sites/wnc.lu.se/files/lindvall_et_al_arch_neurology_1989.pdf

untitled Lewy bodies in grafted neurons in subjects with Parkinson’s disease suggest host-to-graft disease propagation Jia-Yi Li1, Elisabet Englund2, Janice L Holton3, Denis Soulet1, Peter Hagell4, Andrew J Lees3, Tammaryn Lashley3, Niall…

https://www.wnc.lu.se/sites/wnc.lu.se/files/nm1746_0.pdf

Generation of high-purity human ventral midbrain dopaminergic progenitors for in vitro maturation and intracerebral transplantation © 2 01 7 N at u re A m er ic a, In c. , p ar t o f S p ri n g er N at u re . A ll ri g h ts r es er ve d . …

https://www.wnc.lu.se/sites/wnc.lu.se/files/nprot.2017.078.pdf

doi:10.1093/brain/awh649 Brain (2005), 128, 2977–2986 Factors affecting the clinical outcome after neural transplantation in Parkinson’s disease Paola Piccini,1 Nicola Pavese,1 Peter Hagell,3,4 Jan Reimer,3 Anders Björklund,5 Wolfgang H…

https://www.wnc.lu.se/sites/wnc.lu.se/files/piccini_et_al_brain_2005.pdf

nature neuroscience • volume 2 no 12 • december 1999 1137 Cell transplantation in Parkinson’s disease (PD) aims at correct- ing the impairment of striatal dopaminergic neurotransmission caused by degeneration of substantia nigra neurons…

https://www.wnc.lu.se/sites/wnc.lu.se/files/piccini_et_al_nature_neurosci_1989.pdf

Politis 1..7 DOI: 10.1126/scitranslmed.3000976 , 38ra46 (2010);2 Sci Transl Med , et al.Marios Politis Patients with Neural Transplants Serotonergic Neurons Mediate Dyskinesia Side Effects in Parkinson's Editor's Summary The Two Faces of…

https://www.wnc.lu.se/sites/wnc.lu.se/files/politis_et_al_sci_transl_med_2010.pdf

https://www.wnc.lu.se/sites/wnc.lu.se/files/1-s2.0-s2211124712001222-main.pdf

Extensive graft-derived dopaminergic innervation is maintained 24 years after transplantation in the degenerating parkinsonian brain Extensive graft-derived dopaminergic innervation is maintained 24 years after transplantation in the…

https://www.wnc.lu.se/sites/wnc.lu.se/files/6544.full_.pdf

Microsoft Word - Acta3.doc

https://www.wnc.lu.se/sites/wnc.lu.se/files/acta_physiol_scand_suppl._522_19-28_1983.pdf